Styrene maleic acid derivates to enhance the applications of bio-inspired polymer based lipid-nanodiscs
نویسندگان
چکیده
منابع مشابه
SMA-SH: Modified Styrene-Maleic Acid Copolymer for Functionalization of Lipid Nanodiscs.
Challenges in purification and subsequent functionalization of membrane proteins often complicate their biochemical and biophysical characterization. Purification of membrane proteins generally involves replacing the lipids surrounding the protein with detergent molecules, which can affect protein structure and function. Recently, it was shown that styrene-maleic acid copolymers (SMA) can disso...
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Once removed from their natural environment, membrane proteins depend on membrane-mimetic systems to retain their native structures and functions. To this end, lipid-bilayer nanodiscs that are bounded by scaffold proteins or amphiphilic polymers such as styrene/maleic acid (SMA) copolymers have been introduced as alternatives to detergent micelles and liposomes for in vitro membrane-protein res...
متن کاملRecent developments in maleic acid synthesis from bio-based chemicals
This review paper presents the current state of the art on maleic acid synthesis from biomass-derived chemicals over homogeneous or heterogeneous catalysts. It is based on the most recent publications on the topic, which are discussed in details with respect to the observed catalytic performances. The recent developments and the technical drawbacks in the gas and the liquid phases are also repo...
متن کاملSynthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates.
Two types of polymer-drug conjugates were synthesized starting from styrene-maleic acid anhydride copolymer (SMA). Fenoprofen and gemfibrozil were chosen as model drugs because of their short plasma half lives. Both drugs were first converted to their 2-aminoethylamides, which possess free amino groups capable of reacting with SMA anhydride rings. By modifying the degree and type of substitutio...
متن کاملGPCR-styrene maleic acid lipid particles (GPCR-SMALPs): their nature and potential.
G-protein-coupled receptors (GPCRs) form the largest class of membrane proteins and are an important target for therapeutic drugs. These receptors are highly dynamic proteins sampling a range of conformational states in order to fulfil their complex signalling roles. In order to fully understand GPCR signalling mechanisms it is necessary to extract the receptor protein out of the plasma membran...
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ژورنال
عنوان ژورنال: European Polymer Journal
سال: 2018
ISSN: 0014-3057
DOI: 10.1016/j.eurpolymj.2018.09.048